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Thursday 01 August 2002

In vitro studies with bendamustine: enhanced activity in combination with rituximab.

By: Rummel MJ, Chow KU, Hoelzer D, Mitrou PS, Weidmann E.

Semin Oncol 2002 Aug;29(4 Suppl 13):12-4

Studies in vitro have shown that bendamustine, given as a monotherapy or in combination, can induce apoptosis in many cell types, including B-cell chronic lymphocytic leukemia and low-grade lymphoma cells. Evidence is accumulating to suggest that bendamustine may also have synergistic effects in combination therapies. Rituximab is a promising new agent for the treatment of hematologic malignancies and has been shown to have synergistic actions with other chemotherapeutic agents. The actions of the combination of bendamustine and rituximab on ex vivo B-cell chronic lymphocytic leukemia cells and the DOHH-2 cell line, derived from CD20-positive lymphoma cells, are discussed in this article. Copyright 2002, Elsevier Science (USA). All rights reserved.

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