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Sunday 01 February 2004

Successful treatment of diffuse large B-cell lymphoma following Waldenstrom's macroglobulinemia with CHOP chemotherapy followed by combination therapy of CHOP with rituximab.

By: Uchino K, Sameshima H, Miyamoto T, Iino T, Kato K, Henzan H, Aoki K, Nagafuji K, Gondo H, Harada M.

Intern Med 2004 Feb;43(2):131-4

We report a 72-year-old man with Waldenstrom's macroglobulinemia (WM) in whom diffuse large B-cell lymphoma (DLCL) occurred 17 years after the diagnosis of WM. The malignant cells of both DLCL and WM expressed CD20 on their surface. CHOP plus anti-CD20 monoclonal antibody, rituximab, were effective for both diseases, and the patient remains disease-free 17 months later.

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