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Tuesday 01 June 2004

Intraventricular treatment of relapsed central nervous system lymphoma with the anti-CD20 antibody rituximab.

By: Schulz H, Pels H, Schmidt-Wolf I, Zeelen U, Germing U, Engert A.

Haematologica 2004 Jun;89(6):753-4

Most patients with primary central nervous system (CNS) lymphoma or systemic non-Hodgkin's lymphoma (NHL) involving the CNS relapse after an initial response to treatment, often presenting with leptomeningeal disease. Since the majority of these lymphomas are B-cell neoplasms expressing the CD20 surface antigen treatment with the chimeric monoclonal antibody (Mab) rituximab might be a new therapeutic option. Here, we report on 6 patients with relapsed CNS B-cell lymphoma who were treated with intraventricular or intrathecal applications of rituximab. One of these cases has already been reported.

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