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Tuesday 01 June 2004

Rituximab-induced remission of a gastric MALT lymphoma.

By: Datta YH, Kampalath B, Binion DG.

Leuk Lymphoma 2004 Jun;45(6):1297-9

Gastric MALT lymphoma is usually associated with H. pylori infection, and responds to treatment with antibiotics and a proton pump inhibitor. We report a case of H. pylori negative gastric MALT lymphoma. The patient was followed conservatively for 2 years until she developed gastrointestinal bleeding with significant anemia. She was treated with rituximab 375 mg/m2 weekly for four doses, which resulted in a biopsy proven complete remission. Rituximab therapy is a reasonable, well tolerated treatment alternative for MALT lymphomas not associated with H. pylori.

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