Custom Search


Friday 01 October 2004

[Rituximab and autoimmune disorders therapy]

By: Quint L.

Rev Med Interne 2004 Oct;25(10):752-4

INTRODUCTION: B lymphocytes play a central role in pathogenesis of autoimmune disease. This suggests that therapies directed against B lymphocytes may be effective for the treatment of human autoimmune mediated disease. EXEGESIS: Rituximab is a chimeric monoclonal antibody directed against the CD20 antigen expressed on most B cells and is used to treat B cell non Hodgkin lymphoma. Rituximab is highly effective in depleting B lymphocytes in vivo. Such treatment could presumably eliminate B cells producing autoantibodies. Main mechanisms of action of Rituximab are discussed with implication in the management of autoimmune diseases. CONCLUSION: Use of Rituximab for autoimmune disorders therapy is attractive because of its effect on B lymphocytes. However, therapeutics indications have to be adapted to the inherent differences in the pathogenesis of autoimmune diseases to assess efficiency.

Use of this site is subject to the following terms of use