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Saturday 01 January 2005

Precore mutant hepatitis B reactivation after treatment with CHOP-rituximab.

By: Zell JA, Yoon EJ, Ignatius Ou SH, Hoefs JC, Chang JC.

Anticancer Drugs 2005 Jan;16(1):83-5

A patient with stage IV non-Hodgkin's lymphoma and chronic hepatitis who was treated with chemotherapy and rituximab developed fatal reactivation of hepatitis B. High viral load titers of hepatitis B DNA were demonstrated. DNA sequencing analysis revealed the presence of the precore mutant strain. Hepatitis B reactivation in patients receiving rituxmab-based chemotherapy is reviewed and the role of precore mutant virus strains resulting in fatal complications is discussed.

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