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Wednesday 01 February 2006

Rapid growth of Merkel cell carcinoma after treatment with rituximab.

By: Wirges ML, Saporito F, Smith J.

J Drugs Dermatol 2006 Feb;5(2):180-1

Merkel cell carcinoma is an uncommon neuroendocrine carcinoma of the skin. We report a case of rapid growth of Merkel cell carcinoma after treatment with rituximab, a new anti-CD20 monoclonal antibody, for acquired factor VIII inhibitor. We propose that rituximab may place patients at higher risk for aggressive Merkel cell carcinoma thus necessitating the need for increased long-term surveillance of these patients.

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