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Monday 01 May 2006

Estimating the impact of rituximab on bcl-2-associated resistance to CHOP in elderly patients with diffuse large B-cell lymphoma.

By: Mounier N, Briere J, Gisselbrecht C, Reyes F, Gaulard P, Coiffier B; Groupe d'Etude des Lymphomes de l'Adulte.

Haematologica 2006 May;91(5):715-6

Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negative patients without increasing the risk of death in complete remission.

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